Create layout at the final output size.
Convert to Outlines all objects, text, font and images.
From the Tool Bar Menu click on Arrange -> Convert to Outlines
If layout was not created in final output size, save resolution at 300 dpi
Note: Increasing and re-saving resolution to 300 dpi from a layout previously saved at a 72 dpi likely result in a blurry image and not printable.
Save As Format: .AI or .EPS in CMYK
Export As: .AI (Adobe Illustrator Version 8)